Mesotherapy is a treatment designed to stimulate the dermis, or middle layer of the skin. Developed in France in the 1950’s, naturopathic or medical solutions were injected into the dermis to stimulate skin rejuvenation. Now days, there is special technology able to transfer therapeutical solutions without needle. Needle-Free Mesotherapy, or electroporation, is a Noble Prize technology based o the momentary creation of small pores in cell membranes by applying an electrical pulse. Electroporation is also known as electropermeabilization. Here, an electrical field is applied to cells which increases the permeability of the cell membrane hence allowing treatment solutions to be introduced to the cells. With this technology, we infuse different medical grade or naturopathic solutions such us hyaluronic acid, anti aging, anti acne or anti inflammatory peptides, anti oxidants and other substances into the dermal level of skin without needles, improving different skin conditions. Mesotherapy performed with a needle is still actual method of aesthetic medicine delivering treatment solutions to the dermis. Depending on the skin conditions, the method of choice is determined individually.